3-Oxo-3-(3-pyrazol-1-yl-phenyl)-propionic acid tert-butyl ester → {4-Chloro-5-dimethylamino-2-[3-oxo-3-(3-pyrazol-1-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert.-butyl ester

HRID 1265681Notes

Reaction equation

HRID 1265681 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([Cl:17])=[CH:10][C:9]=1[NH2:18])([CH3:4])([CH3:3])[CH3:2].C([O:24][C:25](=O)[CH2:26][C:27](=[O:39])[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([N:34]2[CH:38]=[CH:37][CH:36]=[N:35]2)[CH:29]=1)(C)(C)C>>[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([Cl:17])=[CH:10][C:9]=1[NH:18][C:25](=[O:24])[CH2:26][C:27](=[O:39])[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([N:34]2[CH:38]=[CH:37][CH:36]=[N:35]2)[CH:29]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 696875573-Oxo-3-(3-pyrazol-1-yl-phenyl)-propionic acid tert-butyl esterHCID 69688689(2-Amino-4-chloro-5-dimethylamino-phenyl)-carbamic acid tert.-butyl ester

Product 1

HCID 86586838{4-Chloro-5-dimethylamino-2-[3-oxo-3-(3-pyrazol-1-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert.-butyl ester

Procedure

The title compound was prepared from (2-amino-4-chloro-5-dimethylamino-phenyl)-carbamic acid tert.-butyl ester (Example J1) and 3-oxo-3-(3-pyrazol-1-yl-phenyl)-propionic acid tert.-butyl ester (Example K16) according to the general procedure M. Obtained as a light yellow solid (135 mg).

Sources & evidence

ORD record
ord-72067df22c6d4e958fbf9797e0fdbc0e
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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