Trifluoroacetic acid → HCID 10204007, compound

HRID 1265753Notes

Reaction equation

HRID 1265753 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([C:17]#[C:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:10][C:9]=1[NH:25][C:26](=[O:41])[CH2:27][C:28](=O)[C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([N:35]2[CH:39]=[CH:38][N:37]=[N:36]2)[CH:30]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:16][N:14]([CH3:15])[C:12]1[C:11]([C:17]#[C:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:10][C:9]2[NH:25][C:26](=[O:41])[CH2:27][C:28]([C:29]3[CH:34]=[CH:33][CH:32]=[C:31]([N:35]4[CH:39]=[CH:38][N:37]=[N:36]4)[CH:30]=3)=[N:7][C:8]=2[CH:13]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586803HCID 86586803, compound

Product 1

HCID 10204007HCID 10204007, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {5-dimethylamino-2-[3-oxo-3-(3-[1,2,3]triazol-1-yl-phenyl)-propionylamino]-4-phenylethynyl-phenyl}-carbamic acid tert.-butyl ester (Example M5) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an orange solid (76 mg).

Sources & evidence

ORD record
ord-cf1e524eef3b43eba26a6a860f72aa48
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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