Trifluoroacetic acid → 8-(2-Fluoro-phenyl)-4-(3-imidazol-1-yl-phenyl)-7-(2,2,2-trifluoro-ethoxy)-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 1265769Notes

Reaction equation

HRID 1265769 reaction equation
C(OC(=O)[NH:7][C:8]1[C:13]([NH:14][C:15](=[O:30])[CH2:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([N:25]3[CH:29]=[CH:28][N:27]=[CH:26]3)[CH:20]=2)=O)=[CH:12][C:11]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[F:37])=[C:10]([O:38][CH2:39][C:40]([F:43])([F:42])[F:41])[CH:9]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:37][C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=1[C:11]1[C:10]([O:38][CH2:39][C:40]([F:42])([F:43])[F:41])=[CH:9][C:8]2[N:7]=[C:17]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([N:25]4[CH:29]=[CH:28][N:27]=[CH:26]4)[CH:20]=3)[CH2:16][C:15](=[O:30])[NH:14][C:13]=2[CH:12]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586909HCID 86586909, compound

Product 1

HCID 186134028-(2-Fluoro-phenyl)-4-(3-imidazol-1-yl-phenyl)-7-(2,2,2-trifluoro-ethoxy)-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from [2′-fluoro-5-[3-(3-imidazol-1-yl-phenyl)-3-oxo-propionylamino]-2-(2,2,2-trifluoro-ethoxy)-biphenyl-4-yl]-carbamic acid tert.-butyl ester (Example M22) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a brown solid (50 mg).

Sources & evidence

ORD record
ord-775a434e7da24ea38d2562a307ccc9c8
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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