Trifluoroacetic acid → 8-(2-Fluoro-phenyl)-4-[3-(3-methyl-isoxazol-5-yl)-phenyl]-7-(2,2,2-trifluoro-ethoxy)-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 1265770Notes

Reaction equation

HRID 1265770 reaction equation
C(OC(=O)[NH:7][C:8]1[C:13]([NH:14][C:15](=[O:31])[CH2:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]3[O:29][N:28]=[C:27]([CH3:30])[CH:26]=3)[CH:20]=2)=O)=[CH:12][C:11]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[F:38])=[C:10]([O:39][CH2:40][C:41]([F:44])([F:43])[F:42])[CH:9]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:38][C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=1[C:11]1[C:10]([O:39][CH2:40][C:41]([F:42])([F:44])[F:43])=[CH:9][C:8]2[N:7]=[C:17]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([C:25]4[O:29][N:28]=[C:27]([CH3:30])[CH:26]=4)[CH:20]=3)[CH2:16][C:15](=[O:31])[NH:14][C:13]=2[CH:12]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586819HCID 86586819, compound

Product 1

HCID 186132058-(2-Fluoro-phenyl)-4-[3-(3-methyl-isoxazol-5-yl)-phenyl]-7-(2,2,2-trifluoro-ethoxy)-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from [2′-fluoro-5-{3-[3-(3-methyl-isoxazol-5-yl)-phenyl]-3-oxo-propionylamino}-2-(2,2,2-trifluoro-ethoxy)-biphenyl-4-yl]-carbamic acid tert.-butyl ester (Example M23) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (21 mg).

Sources & evidence

ORD record
ord-ae87d033a1064bb28ced9410caf8ebe5
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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