HRID1265770

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：Cc1cc(-c2cccc(C(=O)CC(=O)Nc3cc(-c4ccccc4F)c(OCC(F)(F)F)cc3NC(=O)OC(C)(C)C)c2)on1

HCID86586819

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(-c2cccc(C3=Nc4cc(OCC(F)(F)F)c(-c5ccccc5F)cc4NC(=O)C3)c2)on1

HCID18613205

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

The title compound was prepared from [2′-fluoro-5-{3-[3-(3-methyl-isoxazol-5-yl)-phenyl]-3-oxo-propionylamino}-2-(2,2,2-trifluoro-ethoxy)-biphenyl-4-yl]-carbamic acid tert.-butyl ester (Example M23) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (21 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ae87d033a1064bb28ced9410caf8ebe5
来源数据集: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06544985B2
来源说明: uspto-grants-2003_04

反应 SMILES

C(OC(=O)[NH:7][C:8]1[C:13]([NH:14][C:15](=[O:31])[CH2:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]3[O:29][N:28]=[C:27]([CH3:30])[CH:26]=3)[CH:20]=2)=O)=[CH:12][C:11]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[F:38])=[C:10]([O:39][CH2:40][C:41]([F:44])([F:43])[F:42])[CH:9]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:38][C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=1[C:11]1[C:10]([O:39][CH2:40][C:41]([F:42])([F:44])[F:43])=[CH:9][C:8]2[N:7]=[C:17]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([C:25]4[O:29][N:28]=[C:27]([CH3:30])[CH:26]=4)[CH:20]=3)[CH2:16][C:15](=[O:31])[NH:14][C:13]=2[CH:12]=1