Trifluoroacetic acid → HCID 18613069, compound

HRID 1265772Notes

Reaction equation

HRID 1265772 reaction equation
C(OC(=O)[NH:7][C:8]1[C:13]([NH:14][C:15](=[O:38])[CH2:16][C:17](=O)[C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([N:24]3[C:28]([CH2:29][O:30]C4CCCCO4)=[CH:27][N:26]=[N:25]3)[CH:19]=2)=[CH:12][C:11]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=2[F:45])=[C:10]([O:46][CH2:47][C:48]([F:51])([F:50])[F:49])[CH:9]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:45][C:40]1[CH:41]=[CH:42][CH:43]=[CH:44][C:39]=1[C:11]1[C:10]([O:46][CH2:47][C:48]([F:51])([F:50])[F:49])=[CH:9][C:8]2[N:7]=[C:17]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([N:24]4[C:28]([CH2:29][OH:30])=[CH:27][N:26]=[N:25]4)[CH:19]=3)[CH2:16][C:15](=[O:38])[NH:14][C:13]=2[CH:12]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586821HCID 86586821, compound

Product 1

HCID 18613069HCID 18613069, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (RS)-[2′-fluoro-5-(3-oxo-3-{3-[5-(tetrahydro-pyran-2-yloxymethyl)-[1,2,3]triazol-1-yl]-phenyl}-propionylamino)-2-(2,2,2-trifluoro-ethoxy)-biphenyl-4-yl]-carbamic acid tert.-butyl ester (Example M25) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (10 mg).

Sources & evidence

ORD record
ord-4bfc0fa1a46a41ffae175928f551910b
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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