Trifluoroacetic acid → HCID 18613303, compound

HRID 1265784Notes

Reaction equation

HRID 1265784 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([Cl:17])=[CH:10][C:9]=1[NH:18][C:19](=[O:43])[CH2:20][C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([C:29]2[N:30]([CH3:42])[N:31]=[C:32]([CH2:34][O:35]C3CCCCO3)[CH:33]=2)[CH:24]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:17][C:11]1[C:12]([N:14]([CH3:16])[CH3:15])=[CH:13][C:8]2[N:7]=[C:21]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([C:29]4[N:30]([CH3:42])[N:31]=[C:32]([CH2:34][OH:35])[CH:33]=4)[CH:24]=3)[CH2:20][C:19](=[O:43])[NH:18][C:9]=2[CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586830HCID 86586830, compound

Product 1

HCID 18613303HCID 18613303, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (RS)-[4-chloro-5-dimethylamino-2-(3-{3-[2-methyl-5-(tetrahydro-pyran-2-yloxymethyl)-2H-pyrazol-3-yl]-phenyl}-3-oxo-propionylamino)-phenyl]-carbamic acid tert.-butyl ester (Example M35) (278 mg, 0.44 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (129 mg).

Sources & evidence

ORD record
ord-f0f3ae8b01114d6a9b58d415e03bc4ef
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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