Trifluoroacetic acid → HCID 18613286, compound

HRID 1265794Notes

Reaction equation

HRID 1265794 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[NH:21][C:22](=[O:45])[CH2:23][C:24](=O)[C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]2[CH:35]=[C:34]([CH2:36][O:37]C3CCCCO3)[O:33][N:32]=2)[CH:26]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:16][N:14]([CH3:15])[C:12]1[C:11]([C:17]([F:18])([F:19])[F:20])=[CH:10][C:9]2[NH:21][C:22](=[O:45])[CH2:23][C:24]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([C:31]4[CH:35]=[C:34]([CH2:36][OH:37])[O:33][N:32]=4)[CH:26]=3)=[N:7][C:8]=2[CH:13]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586913HCID 86586913, compound

Product 1

HCID 18613286HCID 18613286, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (RS)-[5-dimethylamino-2-(3-oxo-3-{3-[5-(tetrahydro-pyran-2-yloxymethyl)-isoxazol-3-yl]-phenyl}-propionylamino)-4-trifluoromethyl-phenyl]-carbamic acid tert.-butyl ester (Example M45) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (103 mg).

Sources & evidence

ORD record
ord-62b94939c02e40b0be36fe04969ed852
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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