Trifluoroacetic acid → HCID 18613106, compound

HRID 1265804Notes

Reaction equation

HRID 1265804 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:17][CH2:16][CH2:15]2)[C:11]([C:18]([F:21])([F:20])[F:19])=[CH:10][C:9]=1[NH:22][C:23](=[O:35])[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][N:30]=[C:29]([C:33]#[N:34])[CH:28]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:14]1([C:12]2[C:11]([C:18]([F:19])([F:21])[F:20])=[CH:10][C:9]3[NH:22][C:23](=[O:35])[CH2:24][C:25]([C:27]4[CH:32]=[CH:31][N:30]=[C:29]([C:33]#[N:34])[CH:28]=4)=[N:7][C:8]=3[CH:13]=2)[CH2:15][CH2:16][CH2:17]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586844{5-Azetidin-1-yl-2-[3-(2-cyano-pyridin-4-yl)-3-oxo-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert.-butyl ester

Product 1

HCID 18613106HCID 18613106, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {5-azetidin-1-yl-2-[3-(2-cyano-pyridin-4-yl)-3-oxo-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert.-butyl ester (Example M52) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an orange solid (51 mg).

Sources & evidence

ORD record
ord-fc7e007b2498445fad4a9a175347f444
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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