Trifluoroacetic acid → 7-Azetidin-1-yl-4-[3-(3-methyl-isoxazol-5-yl)-phenyl]-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 1265805Notes

Reaction equation

HRID 1265805 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:17][CH2:16][CH2:15]2)[C:11]([C:18]([F:21])([F:20])[F:19])=[CH:10][C:9]=1[NH:22][C:23](=[O:39])[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]2[O:37][N:36]=[C:35]([CH3:38])[CH:34]=2)[CH:28]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:14]1([C:12]2[C:11]([C:18]([F:21])([F:19])[F:20])=[CH:10][C:9]3[NH:22][C:23](=[O:39])[CH2:24][C:25]([C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([C:33]5[O:37][N:36]=[C:35]([CH3:38])[CH:34]=5)[CH:28]=4)=[N:7][C:8]=3[CH:13]=2)[CH2:17][CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586845HCID 86586845, compound

Product 1

HCID 186131297-Azetidin-1-yl-4-[3-(3-methyl-isoxazol-5-yl)-phenyl]-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (5-azetidin-1-yl-2-{3-[3-(3-methyl-isoxazol-5-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic acid tert.-butyl ester (Example M53) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (94 mg).

Sources & evidence

ORD record
ord-28d901403d7c4bf3a38f20c9f5c76339
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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