Trifluoroacetic acid → HCID 18613501, compound

HRID 1265818Notes

Reaction equation

HRID 1265818 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[NH:21][C:22](=[O:34])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]#[N:33])[CH:27]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:15][N:14]([CH3:16])[C:12]1[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]2[NH:21][C:22](=[O:34])[CH2:23][C:24]([C:26]3[CH:27]=[C:28]([CH:29]=[CH:30][CH:31]=3)[C:32]#[N:33])=[N:7][C:8]=2[CH:13]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586858HCID 86586858, compound

Product 1

HCID 18613501HCID 18613501, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {2-[3-(3-cyano-phenyl)-3-oxo-propionyl-amino]-5-dimethylamino-4-trifluoromethyl-phenyl}-carbamic acid tert.-butyl ester (Example M66) (180 mg, 1.0 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (41 mg).

Sources & evidence

ORD record
ord-9a58b9ba23b64c42bcecfe4c6a0817df
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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