HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 7-Dimethylamino-8-(2-fluoro-phenyl)-4-(3-[1,2,3]triazol-1-yl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 86586862 | HCID 86586862 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7-Dimethylamino-8-(2-fluoro-phenyl)-4-(3-[1,2,3]triazol-1-yl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 18613169 | — |
Reaction Steps
The title compound was prepared from {2-dimethylamino-2′-fluoro-5-[3-oxo-3-(3-[1,2,3]triazol-1-yl-phenyl)-propionylamino]-biphenyl-4-yl}-carbamic acid tert.-butyl ester (Example M70) (810 mg, 1.45 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (61 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06544985B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-f5ac3381168b4c38a9508bad12c2173a |
| Source note | uspto-grants-2003_04 |