Trifluoroacetic acid → 7-Dimethylamino-8-(2-fluoro-phenyl)-4-(3-[1,2,3]triazol-1-yl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 1265827Notes

Reaction equation

HRID 1265827 reaction equation
C(OC(=O)[NH:7][C:8]1[C:13]([NH:14][C:15](=[O:30])[CH2:16][C:17](=O)[C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([N:24]3[CH:28]=[CH:27][N:26]=[N:25]3)[CH:19]=2)=[CH:12][C:11]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[F:37])=[C:10]([N:38]([CH3:40])[CH3:39])[CH:9]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:40][N:38]([CH3:39])[C:10]1[C:11]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[F:37])=[CH:12][C:13]2[NH:14][C:15](=[O:30])[CH2:16][C:17]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([N:24]4[CH:28]=[CH:27][N:26]=[N:25]4)[CH:19]=3)=[N:7][C:8]=2[CH:9]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586862HCID 86586862, compound

Product 1

HCID 186131697-Dimethylamino-8-(2-fluoro-phenyl)-4-(3-[1,2,3]triazol-1-yl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {2-dimethylamino-2′-fluoro-5-[3-oxo-3-(3-[1,2,3]triazol-1-yl-phenyl)-propionylamino]-biphenyl-4-yl}-carbamic acid tert.-butyl ester (Example M70) (810 mg, 1.45 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (61 mg).

Sources & evidence

ORD record
ord-f5ac3381168b4c38a9508bad12c2173a
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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