Trifluoroacetic acid → HCID 10224436, compound

HRID 1265831Notes

Reaction equation

HRID 1265831 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12](OCC(F)(F)F)[C:11]([C:20]([F:23])([F:22])[F:21])=[CH:10][C:9]=1[NH:24][C:25](=[O:37])[CH2:26][C:27]([C:29]1[CH:34]=[CH:33][N:32]=[C:31]([C:35]#[N:36])[CH:30]=1)=O)(C)(C)C.[C:39](O)([C:41]([F:44])([F:43])[F:42])=[O:40]>C(Cl)Cl>[O:37]=[C:25]1[CH2:26][C:27]([C:29]2[CH:34]=[CH:33][N:32]=[C:31]([C:35]#[N:36])[CH:30]=2)=[N:7][C:8]2[CH:13]=[C:12]([O:40][CH2:39][C:41]([F:44])([F:43])[F:42])[C:11]([C:20]([F:23])([F:22])[F:21])=[CH:10][C:9]=2[NH:24]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586863HCID 86586863, compound

Product 1

HCID 10224436HCID 10224436, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from [2-[3-(2-cyano-pyridin-4-yl)-3-oxo-propionylamino]-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert.-butyl ester (Example M75) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (100 mg).

Sources & evidence

ORD record
ord-3882c99c955a4eda8175ac70af98ccaf
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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