Trifluoroacetic acid → HCID 18613476, compound

HRID 1265835Notes

Reaction equation

HRID 1265835 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([N:15]([CH3:19])[CH2:16][CH2:17][CH3:18])=[CH:10][C:9]=1[NH:20][C:21](=O)[CH2:22][C:23]([C:25]1C=C[CH:28]=[C:27]([C:31]#[N:32])[CH:26]=1)=O)(C)(C)C.[C:35](O)([C:37](F)(F)F)=[O:36]>C(Cl)Cl>[CH3:14][C:12]1[C:11]([N:15]([CH3:19])[CH2:16][CH2:17][CH3:18])=[CH:10][C:9]2[N:20]=[C:21]([C:22]3[CH:28]=[C:27]([CH:26]=[CH:25][CH:23]=3)[C:31]#[N:32])[CH2:37][C:35](=[O:36])[NH:7][C:8]=2[CH:13]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586920HCID 86586920, compound

Product 1

HCID 18613476HCID 18613476, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from [2-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-5-methyl-4-(methyl-propyl-amino)-phenyl]-carbamic acid tert-butyl ester (Example M79) (0.17 g, 0.37 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (74 mg, 58%).

Sources & evidence

ORD record
ord-c1642abbeba2457e87f93e9b9ecdb4bc
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

Loading…