Trifluoroacetic acid → HCID 18613273, compound

HRID 1265846Notes

Reaction equation

HRID 1265846 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:18])[CH2:15][CH2:16][CH3:17])[C:11]([C:19]#[N:20])=[CH:10][C:9]=1[NH:21][C:22](=[O:38])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]2[O:36][N:35]=[C:34]([CH3:37])[CH:33]=2)[CH:27]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:37][C:34]1[CH:33]=[C:32]([C:28]2[CH:27]=[C:26]([C:24]3[CH2:23][C:22](=[O:38])[NH:21][C:9]4[CH:10]=[C:11]([C:19]#[N:20])[C:12]([N:14]([CH3:18])[CH2:15][CH2:16][CH3:17])=[CH:13][C:8]=4[N:7]=3)[CH:31]=[CH:30][CH:29]=2)[O:36][N:35]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586876[4-Cyano-2-{3-[3-(3-methyl-isoxazol-5-yl)-phenyl]-3-oxo-propionylamino}-5-(methyl-propyl-amino)-phenyl]-carbamic acid tert-butyl ester

Product 1

HCID 18613273HCID 18613273, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from [4-cyano-2-{3-[3-(3-methyl-isoxazol-5-yl)-phenyl]-3-oxo-propionylamino}-5-(methyl-propyl-amino)-phenyl]-carbamic acid tert-butyl ester (Example M93) (0.36 g, 0.68 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (94 mg, 34%).

Sources & evidence

ORD record
ord-88cfe49aadf947cab8dfc2eaea885b51
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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