HRID1265897

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：Cc1cc(NC(=O)CC(=O)c2cccc(-n3ncnc3COC3CCCCO3)c2)c(NC(=O)OC(C)(C)C)cc1N(C)CC(C)C

HCID86586898

未命名化合物

PRODUCTS

生成物

结构：Cc1cc2c(cc1N(C)CC(C)C)N=C(c1cccc(-n3ncnc3CO)c1)CC(=O)N2

HCID18613386

未命名化合物

收率 73.5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Prepared from (RS)-[5-(isobutyl-methyl-amino)-4-methyl-2-(3-oxo-3-{3-[5-(tetrahydro-pyran-2-yloxymethyl)-[1,2,4]triazol-1-yl]-phenyl}-propionylamino)-phenyl]-carbamic acid tert-butyl ester (Example M116) (0.96 g, 1.51 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a pale brown solid (480 mg, 73%).