Diethyl methylphosphonate → HCID 11141563, compound

HRID 1265954Notes

Reaction equation

[CH3:1][P:2](=[O:9])([O:6][CH2:7][CH3:8])[O:3][CH2:4][CH3:5].C([Li])CCC.[CH3:15][Si:16]([CH3:26])([CH3:25])[C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=1)[CH2:20]Br>C1COCC1>[CH3:15][Si:16]([CH3:25])([CH3:26])[C:17]1[CH:18]=[C:19]([CH2:20][CH2:1][P:2](=[O:9])([O:6][CH2:7][CH3:8])[O:3][CH2:4][CH3:5])[CH:22]=[CH:23][CH:24]=1

Participants

Conditions

Temperature: -10 °C

Procedure

To a solution of diethyl methylphosphonate (2.28 g, 15 mmol) in THF (20 ml) was added n-butyllithium (17 mmol, 1.6 M solution in hexane) at −78° C. After 45 min, the white suspension was added to a solution of the bromide 37 (3.65 g, 15 mmol) in THF (20 ml) and the mixture was stirred for 1.5 h. The temperature was then increased to −10° C. and after 1 h the deeply red colored solution was quenched by addition of saturated NH4Cl (aq). Volatiles were removed under reduced pressure and the residue was purified by flash chromatography (silica, EtOAc) to give 2.48 g (53%) of 38 as a colorless liquid. IR (film): 3473, 2955, 1248, 1058 and 1031; 1H NMR (200 MHz, CDCl3): δ0.30 (9H, s), 1.31 (6H, t, J=7 Hz), 2.10 (2H, m), 2.92 (2H, m), 4.11 (4H, m) and 7.29 (4H, m); 13C NMR (50 MHz, CDCl3): δ−1.2, 16.4, 26.3, 28.6, 29.0, 61.5, 127.9, 128.4, 131.2, 132.9, 139.9, 140.2 and 140.7; HR-MS (EI): e/m 314.1453 (M+C15H27O3PSi requires 314.1467).

Workup

customwas quenched by addition of saturated NH4Cl (aq)
customVolatiles were removed under reduced pressure
customthe residue was purified by flash chromatography (silica, EtOAc)

Sources & evidence

ORD record: ord-52ed8de8d04848289905633b127467e2
Source dataset: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06548042B2

Reaction notes

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