Thionyl Chloride → HCID 69701208, compound

HRID 1266041Notes

Reaction equation

HRID 1266041 reaction equation
O[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:14]3[CH2:15][CH2:16][C:17]4[NH:18][C:19](=[O:22])[CH:20]=[CH:21][C:12]([C:13]=43)=[CH:11][N:10]=2)=[CH:5][CH:4]=1.S(Cl)([Cl:25])=O>C(#N)C>[Cl:25][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:14]3[CH2:15][CH2:16][C:17]4[NH:18][C:19](=[O:22])[CH:20]=[CH:21][C:12]([C:13]=43)=[CH:11][N:10]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 69700490HCID 69700490, compound

Product 1

HCID 69701208HCID 69701208, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

This compound was prepared by reacting 500 mg (1.7 mmol) of alcohol 58a, suspended in 25 mL of acetonitrile with 4 equivalents of thionyl chloride. After complete conversion as determined by HPLC analysis the reaction was concentrated in vacuo and the crude benzylchloride was without further purification. HPLC Rt=3.060 min.

Workup

  1. customThis compound was prepared
  2. concentrationwas concentrated in vacuo
  3. customthe crude benzylchloride was without further purification

Sources & evidence

ORD record
ord-bb7d1793d40848209e5aacd24b776c17
Source dataset
uspto-grants-2003_04
Patent number
US06548494B1

Reaction notes

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