2,5-Bis(trifluoromethyl)aniline → 2-{2,5-bis(trifluoromethyl)phenyl}amino-3-cyclohexyl-6-trifluoromethyl-4(3H)-pyrimidinone

HRID 1266205Notes

Reaction equation

HRID 1266205 reaction equation
[CH:1]1([N:7]2[C:12](=[O:13])[CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[N:9]=[C:8]2SC)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[F:20][C:21]([F:34])([F:33])[C:22]1[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][C:23]=1[NH2:24]>>[F:20][C:21]([F:33])([F:34])[C:22]1[CH:28]=[CH:27][C:26]([C:29]([F:31])([F:32])[F:30])=[CH:25][C:23]=1[NH:24][C:8]1[N:7]([CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[C:12](=[O:13])[CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[N:9]=1

Participants

3

Reactant 2

HCID 7198182,5-Bis(trifluoromethyl)anilineHCID 185492233-Cyclohexyl-2-methylthio-6-trifluoromethyl-4(3H)-pyrimidinone

Product 1

HCID 185492282-{2,5-bis(trifluoromethyl)phenyl}amino-3-cyclohexyl-6-trifluoromethyl-4(3H)-pyrimidinoneYield 60%

Procedure

3-Cyclohexyl-2-methylthio-6-trifluoromethyl-4(3H)-pyrimidinone which had been synthesized in accordance with the method of Example 24 was allowed to react with 2,5-bis(trifluoromethyl)aniline, thereby obtaining white solid of 2-{2,5-bis(trifluoromethyl)phenyl}amino-3-cyclohexyl-6-trifluoromethyl-4(3H)-pyrimidinone [Compound No. 64].

Sources & evidence

ORD record
ord-9337b383916d4c358660eda23e48309f
Source dataset
uspto-grants-2003_04
Patent number
US06548511B1

Reaction notes

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