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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1266205Generated: October 25, 2026

2,5-Bis(trifluoromethyl)aniline → 2-{2,5-bis(trifluoromethyl)phenyl}amino-3-cyclohexyl-6-trifluoromethyl-4(3H)-pyrimidinone

https://huagongshe.com/reaction/1266205

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,5-Bis(trifluoromethyl)anilineHCID 719818—
Reactant3-Cyclohexyl-2-methylthio-6-trifluoromethyl-4(3H)-pyrimidinoneHCID 18549223—
Product2-{2,5-bis(trifluoromethyl)phenyl}amino-3-cyclohexyl-6-trifluoromethyl-4(3H)-pyrimidinoneHCID 1854922860%

Reaction Steps

3-Cyclohexyl-2-methylthio-6-trifluoromethyl-4(3H)-pyrimidinone which had been synthesized in accordance with the method of Example 24 was allowed to react with 2,5-bis(trifluoromethyl)aniline, thereby obtaining white solid of 2-{2,5-bis(trifluoromethyl)phenyl}amino-3-cyclohexyl-6-trifluoromethyl-4(3H)-pyrimidinone [Compound No. 64].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06548511B1
Source datasetuspto-grants-2003_04
ORD IDord-9337b383916d4c358660eda23e48309f
Source noteuspto-grants-2003_04