Pyridine → HCID 4146887, compound

HRID 1266215Notes

Reaction equation

HRID 1266215 reaction equation
[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8](Cl)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C(N)CCCC>ClCCl>[CH2:18]([NH:17][C:8](=[O:9])[CH:7]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH2:19][CH2:20][CH2:21][CH3:22]

Participants

5

Reactant 3

HCID 1049PyridineHCID 8060PentylamineHCID 746372,2-Diphenylacetyl chloride

Product 1

HCID 4146887HCID 4146887, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a cooled (0° C.) solution diphenylacetyl chloride (1.73 mmol) and pyridine (0.28 ml, 3.46 mmol) in dichloromethane (12 ml) was added pentylamine (0.39 ml, 2.60 mmol) and the reaction mixture was stirred at RT for 16 h. Aqueous work up and crystallization from ethyl acetate/hexane yielded the product as a light yellow solid, m.p. 101° C. and MS: m/e=281 (M+).

Workup

  1. customAqueous work up and crystallization from ethyl acetate/hexane

Sources & evidence

ORD record
ord-d3545ab174934144b29083778cb0c21f
Source dataset
uspto-grants-2003_04
Patent number
US06548522B1

Reaction notes

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