2,2-Diphenylacetyl chloride → 2,2-Diphenyl-N-(4,4,4-trifluoro-butyl)-acetamide

HRID 1266240Notes

Reaction equation

HRID 1266240 reaction equation
[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8](Cl)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:17][C:18]([F:24])([F:23])[CH2:19][CH2:20][CH2:21][NH2:22]>>[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([NH:22][CH2:21][CH2:20][CH2:19][C:18]([F:24])([F:23])[F:17])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 746372,2-Diphenylacetyl chlorideHCID 1366454,4,4-Trifluorobutylamine

Product 1

HCID 185496952,2-Diphenyl-N-(4,4,4-trifluoro-butyl)-acetamide

Procedure

The title compound, white solid, m.p. 166° C. and MS: m/e=321 (M+) was prepared in accordance with the general method of example 1 from diphenylacetyl chloride and 4,4,4-trifluoro-butylamine.

Sources & evidence

ORD record
ord-72bf1680ae1e407c9be0608bf8fea30c
Source dataset
uspto-grants-2003_04
Patent number
US06548522B1

Reaction notes

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