反应详情

A mixture of 7.5 g (32 mmol) of 4-chloro-6-nitro-[1.8]naphthyridine-3-carbonitrile and 5.5 g (32 mmol) of 3-bromo-aniline in 175 ml of isopropanol was stirred at reflux for 2 hr. and 45 min. The mixture was cooled, solid was collected, and washed with ether giving 12.9 g of the title compound as the yellow hydrochloride salt: mass spectrum (electrospray, m/e): M+H 370, 373.

1. temperatureat reflux for 2 hr
2. custom45 min
3. temperatureThe mixture was cooled
4. customsolid was collected
5. washwashed with ether giving 12.9 g of the title compound as the yellow hydrochloride salt