反应详情

A solution of 1-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-5-(3-methyl-thiophen-2-yl)-1H-pyrimidine-2,4-dione (Prep 27, 73 mg, 0.2 mmol) in dioxane (8 mL) was cooled at 0° C. and then 4N HCl in dioxane (0.5 mL) was added. The mixture was stirred for 1 hour at room temperature and then the solvent was evaporated. The crude was purified by trituration with diisopropylether to afford the title compound as a white solid (36 mg, 72% yield).

1. customthe solvent was evaporated
2. customThe crude was purified by trituration with diisopropylether