HRID1266324

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24758

Sodium hydride

HNa

HCID809740

未命名化合物

结构：CCOC(=O)c1cnc2c(c(C)nn2-c2ccccc2)c1Cl

HCID11771453

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cnc2c(c(C)nn2-c2ccccc2)c1N(Cc1cccnc1)S(=O)(=O)c1ccc(OC)cc1

HCID22322150

未命名化合物

PROCEDURE

实验过程

Following the procedure of Example 53, the product of Example 65 is reacted with (4-methoxybenzenesulfonyl) (3-pyridinylmethyl) amine and sodium hydride to provide ethyl-4-[(4-methoxybenzenesulfonyl)pyridin-3-ylmethylamino]-1-phenyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate. m.p. 1480-150° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f7c4ce620a424fc18b0323b6536cd8bf
来源数据集: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06548524B2
来源说明: uspto-grants-2003_04

反应 SMILES

Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]2[N:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:14]=[C:15]([CH3:16])[C:3]=12.[CH3:23][O:24][C:25]1[CH:30]=[CH:29][C:28]([S:31]([NH:34][CH2:35][C:36]2[CH:37]=[N:38][CH:39]=[CH:40][CH:41]=2)(=[O:33])=[O:32])=[CH:27][CH:26]=1.[H-].[Na+]>>[CH2:11]([O:10][C:8]([C:7]1[C:2]([N:34]([S:31]([C:28]2[CH:29]=[CH:30][C:25]([O:24][CH3:23])=[CH:26][CH:27]=2)(=[O:33])=[O:32])[CH2:35][C:36]2[CH:37]=[N:38][CH:39]=[CH:40][CH:41]=2)=[C:3]2[C:15]([CH3:16])=[N:14][N:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:4]2=[N:5][CH:6]=1)=[O:9])[CH3:12]