4-Dimethylaminobutylamine → 5-[3-(4-Dimethylamino-butyl)-ureido]-3-(2,3,6-trifluoro-4-methyl-benzyloxy) isothiazole-4-carboxylic acid amide

HRID 1266396Notes

Reaction equation

HRID 1266396 reaction equation
C1(O[C:8](=[O:30])[NH:9][C:10]2[S:14][N:13]=[C:12]([O:15][CH2:16][C:17]3[C:22]([F:23])=[CH:21][C:20]([CH3:24])=[C:19]([F:25])[C:18]=3[F:26])[C:11]=2[C:27](=[O:29])[NH2:28])C=CC=CC=1.[CH3:31][N:32]([CH3:38])[CH2:33][CH2:34][CH2:35][CH2:36][NH2:37]>>[CH3:31][N:32]([CH3:38])[CH2:33][CH2:34][CH2:35][CH2:36][NH:37][C:8](=[O:30])[NH:9][C:10]1[S:14][N:13]=[C:12]([O:15][CH2:16][C:17]2[C:22]([F:23])=[CH:21][C:20]([CH3:24])=[C:19]([F:25])[C:18]=2[F:26])[C:11]=1[C:27]([NH2:28])=[O:29]

Participants

3

Reactant 2

HCID 770634-DimethylaminobutylamineHCID 54053016[4-Carbamoyl-3-(2,3,6-trifluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl ester

Product 1

HCID 103669415-[3-(4-Dimethylamino-butyl)-ureido]-3-(2,3,6-trifluoro-4-methyl-benzyloxy) isothiazole-4-carboxylic acid amide

Procedure

The title compound was prepared from [4-carbamoyl-3-(2,3,6-trifluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl ester and N,N-dimethyl-butane-1,4-diamine by the procedure analogous to Example 1. MS (APCl, m/z): 460 [M+H]+.

Sources & evidence

ORD record
ord-7c35d492d6f54c54902aef2e14f3beb8
Source dataset
uspto-grants-2003_04
Patent number
US06548526B2

Reaction notes

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