N-bromobutanimide → HCID 18551182, compound

HRID 1266427Notes

Reaction equation

HRID 1266427 reaction equation
C([O:3][C:4](=[O:23])[C:5]([OH:22])([C:18]([F:21])([F:20])[F:19])[CH2:6][C:7]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1)([CH3:9])[CH3:8])C.[Br:24]N1C(=O)CCC1=O>CN(C)C=O>[Br:24][C:12]1[CH:11]=[C:10]([C:7]([CH3:9])([CH3:8])[CH2:6][C:5]([OH:22])([C:18]([F:21])([F:20])[F:19])[C:4]([OH:3])=[O:23])[CH:15]=[CH:14][C:13]=1[O:16][CH3:17]

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 17935632HCID 17935632, compound

Product 1

HCID 18551182HCID 18551182, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

From 2-hydroxy-4-(4-methoxyphenyl)-4-methyl-2-trifluoromethyl-valeric acid ethyl ester by bromation with N-bromosuccinimide in dimethylformamide at 0° C. and subsequent saponification. Melting point 94-96° C.

Workup

  1. customat 0° C.

Sources & evidence

ORD record
ord-26c5c107e33c4dab8e412888dd41bd7a
Source dataset
uspto-grants-2003_04
Patent number
US06548534B2

Reaction notes

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