2,4-Difluorobenzaldehyde → E-2,4-difluorostyryl 4-fluorobenzyl sulfone

HRID 1266487Notes

Reaction equation

HRID 1266487 reaction equation
[F:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][S:7]([CH2:10][C:11](O)=O)(=[O:9])=[O:8])=[CH:4][CH:3]=1.[F:16][C:17]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:18]=1C=O>>[F:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][S:7](/[CH:10]=[CH:11]/[C:22]2[CH:21]=[CH:18][C:17]([F:16])=[CH:24][C:23]=2[F:25])(=[O:9])=[O:8])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 737702,4-DifluorobenzaldehydeHCID 11447598[(4-Fluorobenzyl)sulfonyl]acetic acid

Product 1

HCID 9883232E-2,4-difluorostyryl 4-fluorobenzyl sulfoneYield 68%

Procedure

A solution of 4-fluorobenzyl sulfonylacetic acid (0.01 mol) and 2,4difluorobenzaldehyde (0.01 mol) was subjected to Procedure 1. The title compound was obtained in 68% yield.

Sources & evidence

ORD record
ord-0dbaf2480bbe4108a5e8868157cf920f
Source dataset
uspto-grants-2003_04
Patent number
US06548553B2

Reaction notes

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