反应详情

温度

80 °C

1.0 g of 1,1-dimethylethyl 2-[[4-[2-[(2-ethoxy-2-oxoethyl)(2-furanylmethyl)amino]-ethyl]phenyl]-thio]-2-methyl-propanoate is treated with 6.5 ml of 1 N NaOH in 10 ml of ethanol. The mixture is stirred at 80° C. for 1 h, concentrated, dissolved in water and acidified with 1 N HCl. Three extractions with ethyl acetate and chromatography (dichloromethane/methanol 5+1) gives 744 mg as a colourless oil.

1. concentrationconcentrated
2. dissolutiondissolved in water
3. extractionThree extractions with ethyl acetate and chromatography (dichloromethane/methanol 5+1)
4. customgives 744 mg as a colourless oil