HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1266514Generated: November 1, 2026
Sodium Hydroxide → 1,1-Dimethylethyl 2-[[4-[2-[(carboxymethyl)(2-furanylmethyl)amino]ethyl]phenyl]thio]-2-methyl-propanoate
https://huagongshe.com/reaction/1266514
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 22708226 | HCID 22708226 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1,1-Dimethylethyl 2-[[4-[2-[(carboxymethyl)(2-furanylmethyl)amino]ethyl]phenyl]thio]-2-methyl-propanoate | HCID 22708252 | — |
Reaction Steps
1.0 g of 1,1-dimethylethyl 2-[[4-[2-[(2-ethoxy-2-oxoethyl)(2-furanylmethyl)amino]-ethyl]phenyl]-thio]-2-methyl-propanoate is treated with 6.5 ml of 1 N NaOH in 10 ml of ethanol. The mixture is stirred at 80° C. for 1 h, concentrated, dissolved in water and acidified with 1 N HCl. Three extractions with ethyl acetate and chromatography (dichloromethane/methanol 5+1) gives 744 mg as a colourless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06548538B2 |
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| Source dataset | uspto-grants-2003_04 |
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| ORD ID | ord-51d17c4cba9745bd8a07072cb5ff8738 |
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| Source note | uspto-grants-2003_04 |
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