Hydrazine → HCID 74990038, compound

HRID 1266656Notes

Reaction equation

HRID 1266656 reaction equation
[F:1][C:2]([CH3:33])([CH3:32])[CH2:3][CH2:4][CH:5]1[C:9](=[O:10])[O:8][CH:7]([CH:11]([NH:19][C:20]([C:22]2[CH:31]=[N:30][C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[N:23]=2)=[O:21])[CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:6]1.[NH2:34][NH2:35]>CO>[CH2:12]([CH:11]([NH:19][C:20]([C:22]1[CH:31]=[N:30][C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[N:23]=1)=[O:21])[CH:7]([OH:8])[CH2:6][CH:5]([C:9]([NH:34][NH2:35])=[O:10])[CH2:4][CH2:3][C:2]([F:1])([CH3:33])[CH3:32])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 76502387HCID 76502387, compound

Product 1

HCID 74990038HCID 74990038, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of quinoxaline-2-carboxylic acid {1-[4-(3-fluoro-3-methyl-butyl)-5-oxo-tetrahydro-furan-2-yl]-2-phenyl-ethyl}-amide (220 mg, 0.489 mmol) in methanol (5 mL) was added excess hydrazine (0.500 mL) and stirred for 18 hours. The reaction was concentrated to give the title compound (222 mg, 94%).

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-8d2f8e1f1e924c33853eb0113b5fdf1f
Source dataset
uspto-grants-2003_04
Patent number
US06548671B2

Reaction notes

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