反应详情

Isobutyrophenone (30.0 g, 0.20 mole) was dissolved in heptane (10 ml) and sulfuryl chloride (35 g, 0.26 mole) was added at once. After a few minutes gas evolution occurred. After 3 h of stirring at room temperature the reaction mixture was concentrated. The concentrate was dissolved in heptane (250 ml) and washed with 150 ml of an aqueous 2 wt % sodium bicarbonate solution. After drying over magnesium sulfate the solvent was removed under reduced pressure. The yield of 2-chloro-2-methylpropiophenone was 36.4 g or 98%.

1. waitAfter a few minutes gas evolution occurred
2. concentrationwas concentrated
3. dissolutionThe concentrate was dissolved in heptane (250 ml)
4. washwashed with 150 ml of an aqueous 2 wt % sodium bicarbonate solution
5. dry with materialAfter drying over magnesium sulfate the solvent
6. customwas removed under reduced pressure