Methanol → HCID 22317920, compound

HRID 1266731Notes

Reaction equation

HRID 1266731 reaction equation
Cl[C:2]1[C:3]([C:12]([F:15])([F:14])[F:13])=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:8])[CH:7]=1.[OH-:16].[K+].[CH3:18]O>CS(C)=O>[CH3:18][O:16][C:2]1[C:3]([C:12]([F:15])([F:14])[F:13])=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:8])[CH:7]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 27738135-Chloro-2-nitro-4-(trifluoromethyl)aniline

Product 1

HCID 22317920HCID 22317920, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The title compound was prepared from 5-chloro-2-nitro-4-trifluoromethyl-phenylamine [CAS-No. 35375-74-7] (4.61 g, 19.2 mmol) and KOH (2.78 g, 42.2 mmol) in MeOH (20 mL) and DMSO (40 mL) according to the general procedure E. Obtained as a yellow solid (4.18 g).

Sources & evidence

ORD record
ord-08db82a560ce4e2bbf623c741520db92
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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