Ethanol → 5-Ethoxy-2-nitro-4-(trifluoromethyl)aniline

HRID 1266732Notes

Reaction equation

HRID 1266732 reaction equation
Cl[C:2]1[C:3]([C:12]([F:15])([F:14])[F:13])=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:8])[CH:7]=1.[OH-].[K+].[CH3:18][CH2:19][OH:20]>CS(C)=O>[CH2:19]([O:20][C:2]1[C:3]([C:12]([F:15])([F:14])[F:13])=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:8])[CH:7]=1)[CH3:18]

Participants

5

Reactant 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 27738135-Chloro-2-nitro-4-(trifluoromethyl)aniline

Product 1

HCID 223171555-Ethoxy-2-nitro-4-(trifluoromethyl)aniline

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The title compound was prepared from 5-chloro-2-nitro-4-trifluoromethyl-phenylamine [CAS-No. 35375-74-7] (7.06 g, 29.3 mmol) and KOH (4.26 g, 64.6 mmol) in EtOH (30 mL) and DMSO (60 mL) according to the general procedure E. Obtained as a yellow solid (4.20 g).

Sources & evidence

ORD record
ord-aa8939a91acb4b2c8a9623b5dc783888
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

Loading…