反应详情

To a cooled suspension of 20 g of γ-hydroxy-N-methylphenylpropylamine.HCl in chloroform are added dropwise 30 ml of thionylchloride. The mixture is subsequently stirred at room temperature till all solid substance has been dissolved. The solvent chloroform and the excess of thionylchloride are distilled off after which the residue is washed with ether and then made alkaline (pH=8) with a sodiumcarbonate solution (10%). The alkaline solution is subsequently extracted with ether and the ether extracts washed with water, dried and evaporated to dryness. The residue (oil) is used without any additional purification (yield 15.6 g; 85%).

1. dissolutionhas been dissolved
2. distillationThe solvent chloroform and the excess of thionylchloride are distilled off after which the residue
3. washis washed with ether
4. extractionThe alkaline solution is subsequently extracted with ether
5. washthe ether extracts washed with water
6. customdried
7. customevaporated to dryness
8. customThe residue (oil) is used without any additional purification (yield 15.6 g; 85%)