Trifluoroacetic anhydride → HCID 22224751, compound

HRID 1266774Notes

Reaction equation

HRID 1266774 reaction equation
[C:1]([O:5][C:6](=[O:18])[CH2:7][C:8]([C:10]1[CH:15]=[CH:14][N:13]=[C:12]([C:16]#[N:17])[CH:11]=1)=[O:9])(C)([CH3:3])[CH3:2].C(OC(C(F)(F)F)=O)(C(F)(F)F)=O>C(O)(C(F)(F)F)=O.CC(C)=O>[CH3:2][C:1]1([CH3:3])[O:9][C:8]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([C:16]#[N:17])[CH:11]=2)=[CH:7][C:6](=[O:18])[O:5]1

Participants

4

Reactant 2

HCID 9845Trifluoroacetic anhydrideHCID 695928163-(2-Cyano-pyridin-4-yl)-3-oxo-propionic acid tert-butyl ester

Product 1

HCID 22224751HCID 22224751, compound

Reagents, catalysts & solvents 1

HCID 86586799TFA acetoneSolvent

Procedure

The title compound was prepared from 3-(2-cyano-pyridin-4-yl)-3-oxo-propionic acid tert.-butyl ester (Example M10) by stirring in TFA/acetone with TFAA according to general procedure L (method b). Obtained as a brown solid (3.30 g).

Sources & evidence

ORD record
ord-64c531f3366740928d9be48e73736cf5
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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