3-(2,2-Dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile → 3-(3-Cyano-phenyl)-N-[5-(3-hydroxymethyl-pyrrol-1-yl)-2-nitro-phenyl]-3-oxo-propionamide
Reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([N:11]2[CH:15]=[CH:14][C:13]([CH2:16][OH:17])=[CH:12]2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].CC1(C)[O:24][C:23]([C:25]2[CH:26]=[C:27]([CH:30]=[CH:31][CH:32]=2)[C:28]#[N:29])=[CH:22][C:21](=O)[O:20]1>>[C:28]([C:27]1[CH:26]=[C:25]([C:23](=[O:24])[CH2:22][C:21]([NH:1][C:2]2[CH:3]=[C:4]([N:11]3[CH:15]=[CH:14][C:13]([CH2:16][OH:17])=[CH:12]3)[CH:5]=[CH:6][C:7]=2[N+:8]([O-:10])=[O:9])=[O:20])[CH:32]=[CH:31][CH:30]=1)#[N:29]Participants
3
Procedure
The title compound was prepared from [1-(3-amino-4-nitro-phenyl)-1H-pyrrol-3-yl]-methanol (Example F5) and 3-(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile (Example L1) according to the general procedure M. Obtained as an orange solid (77 mg).
Sources & evidence
- ORD record
- ord-f3834d1b4b374191a84e9ffaf70e8e0e
- Source dataset
- uspto-grants-2003_04
- Patent number
- US06548495B2
Reaction notes
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