3-(2,2-Dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile → 3-(3-Cyano-phenyl)-N-[2-nitro-5-(3-phenyl-pyrrol-1-yl)-phenyl]-3-oxo-propionamide

HRID 1266792Notes

Reaction equation

HRID 1266792 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:11]2)=[CH:6][C:5]=1[NH2:21])([O-:3])=[O:2].CC1(C)[O:28][C:27]([C:29]2[CH:30]=[C:31]([CH:34]=[CH:35][CH:36]=2)[C:32]#[N:33])=[CH:26][C:25](=O)[O:24]1>>[C:32]([C:31]1[CH:30]=[C:29]([C:27](=[O:28])[CH2:26][C:25]([NH:21][C:5]2[CH:6]=[C:7]([N:10]3[CH:14]=[CH:13][C:12]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)=[CH:11]3)[CH:8]=[CH:9][C:4]=2[N+:1]([O-:3])=[O:2])=[O:24])[CH:36]=[CH:35][CH:34]=1)#[N:33]

Participants

3

Reactant 2

HCID 117363373-(2,2-Dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrileHCID 185488492-Nitro-5-(3-phenyl-pyrrol-1-yl)-phenylamine

Product 1

HCID 185487693-(3-Cyano-phenyl)-N-[2-nitro-5-(3-phenyl-pyrrol-1-yl)-phenyl]-3-oxo-propionamide

Procedure

The title compound was prepared from 2-nitro-5-(3-phenyl-pyrrol-1-yl)-phenylamine (Example F6) and 3-(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile (Example L1) according to the general procedure M. Obtained as an orange solid (267 mg).

Sources & evidence

ORD record
ord-1a757c6edabe4b35bd9d63cd901bfac0
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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