3-(2,2-Dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile → HCID 86586973, compound

HRID 1266798Notes

Reaction equation

HRID 1266798 reaction equation
[C:1]([O:5][C:6](=[O:26])[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[C:11]([N:16]2[CH:20]=[CH:19][CH:18]=[C:17]2[C:21]([CH3:24])([CH3:23])[CH3:22])=[CH:10][C:9]=1[NH2:25])([CH3:4])([CH3:3])[CH3:2].CC1(C)[O:33][C:32]([C:34]2[CH:35]=[C:36]([CH:39]=[CH:40][CH:41]=2)[C:37]#[N:38])=[CH:31][C:30](=O)[O:29]1>>[C:1]([O:5][C:6](=[O:26])[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[C:11]([N:16]2[CH:20]=[CH:19][CH:18]=[C:17]2[C:21]([CH3:24])([CH3:23])[CH3:22])=[CH:10][C:9]=1[NH:25][C:30](=[O:29])[CH2:31][C:32]([C:34]1[CH:41]=[CH:40][CH:39]=[C:36]([C:37]#[N:38])[CH:35]=1)=[O:33])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 117363373-(2,2-Dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrileHCID 69780025HCID 69780025, compound

Product 1

HCID 86586973HCID 86586973, compound

Procedure

The title compound was prepared from [2-amino-4-(2-tert.-butyl-pyrrol-1-yl)-5-methoxy-phenyl]-carbamic acid tert.-butyl ester (Example J5) (89 mg, 0.25 mmol) and 3-(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile (Example L1) (63 mg, 0.275 mmol) according to the general procedure M. Obtained as an off-white solid (72 mg).

Sources & evidence

ORD record
ord-14992c1ce41647fe93abe6a151df1411
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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