6-(3-Imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one → HCID 86586975, compound

HRID 1266800Notes

Reaction equation

HRID 1266800 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([CH2:14][C:15]#[N:16])[C:11]([I:17])=[CH:10][C:9]=1[NH2:18])([CH3:4])([CH3:3])[CH3:2].[N:20]1([C:25]2[CH:26]=[C:27]([C:31]3[O:36]C(C)(C)[O:34][C:33](=O)[CH:32]=3)[CH:28]=[CH:29][CH:30]=2)[CH:24]=[CH:23][N:22]=[CH:21]1>>[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([CH2:14][C:15]#[N:16])[C:11]([I:17])=[CH:10][C:9]=1[NH:18][C:33](=[O:34])[CH2:32][C:31]([C:27]1[CH:28]=[CH:29][CH:30]=[C:25]([N:20]2[CH:24]=[CH:23][N:22]=[CH:21]2)[CH:26]=1)=[O:36])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 222248956-(3-Imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-oneHCID 69781137HCID 69781137, compound

Product 1

HCID 86586975HCID 86586975, compound

Procedure

The title compound was prepared from (2-amino-5-cyanomethyl-4-iodo-phenyl)-carbamic acid tert.-butyl ester (Example J6) (363 mg, 0.973 mmol) and 6-(3-imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one (Example L3) (411 mg, 1.52 mmol) according to the general procedure M. Obtained as a yellow oil (523 mg).

Sources & evidence

ORD record
ord-f3fd74035f6447df843dc1c0cd799e3a
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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