HCID 12048026, compound → HCID 86586985, compound

HRID 1266809Notes

Reaction equation

HRID 1266809 reaction equation
[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[C:11]([C:20]([F:23])([F:22])[F:21])=[CH:10][C:9]=1[NH2:24])([CH3:4])([CH3:3])[CH3:2].C([O:28][C:29](=O)[CH2:30][C:31](=[O:43])[C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([N:38]2[CH:42]=[N:41][N:40]=[CH:39]2)[CH:33]=1)C>>[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[C:11]([C:20]([F:21])([F:22])[F:23])=[CH:10][C:9]=1[NH:24][C:29](=[O:28])[CH2:30][C:31](=[O:43])[C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([N:38]2[CH:39]=[N:40][N:41]=[CH:42]2)[CH:33]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 12048026HCID 12048026, compoundHCID 695928753-Oxo-3-(3-[1,2,4]triazol-4-yl-phenyl)-propionic acid ethyl ester

Product 1

HCID 86586985HCID 86586985, compound

Procedure

The title compound was prepared from (2-amino-5-morpholin-4-yl-4-trifluoromethyl-phenyl)-carbamic acid tert.-butyl ester (Example J1) (434 mg, 1.2 mmol) and 3-oxo-3-(3-[1,2,4]triazol-4-yl-phenyl)-propionic acid ethyl ester [CAS-No. 335255-97-5] (259 mg, 1.0 mmol) according to the general procedure M. Obtained as an off-white solid (372 mg).

Sources & evidence

ORD record
ord-dbf369a9816b4ec8acc4eef8a1080b30
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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