HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-{3-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4-nitro-phenyl}-1H-pyrrole-2-carboxylic acid methyl ester → 1-[2-(3-Cyano-phenyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-7-yl]-1H-pyrrole-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-{3-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4-nitro-phenyl}-1H-pyrrole-2-carboxylic acid methyl ester | HCID 86586970 | — |
| Catalyst | Eisenazetat | HCID 45051903 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | 1-[2-(3-Cyano-phenyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-7-yl]-1H-pyrrole-2-carboxylic acid methyl ester | HCID 69781031 | — |
Reaction Steps
The title compound was prepared from 1-{3-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-4-nitro-phenyl}-1H-pyrrole-2-carboxylic acid methyl ester (Example M15) by reductive cyclization with Fe/HOAc in THF/H2O at 80° C. according to the general procedure J (method d). Obtained as a brown solid (323 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06548495B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-72c492f08bce4c5d9b9da1705dc6ea40 |
| Source note | uspto-grants-2003_04 |