Trifluoroacetic acid → 4-(3-Imidazol-1-yl-phenyl)-8-pyrrol-1-yl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 1266841Notes

Reaction equation

HRID 1266841 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH:18]=[CH:17][CH:16]=[CH:15]2)=[CH:10][C:9]=1[NH:19][C:20](=[O:35])[CH2:21][C:22]([C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([N:30]2[CH:34]=[CH:33][N:32]=[CH:31]2)[CH:25]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:30]1([C:26]2[CH:25]=[C:24]([C:22]3[CH2:21][C:20](=[O:35])[NH:19][C:9]4[CH:10]=[C:11]([N:14]5[CH:18]=[CH:17][CH:16]=[CH:15]5)[CH:12]=[CH:13][C:8]=4[N:7]=3)[CH:29]=[CH:28][CH:27]=2)[CH:34]=[CH:33][N:32]=[CH:31]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586971{2-[3-(3-Imidazol-1-yl-phenyl)-3-oxo-propionylamino]-4-pyrrol-1-yl-phenyl}-carbamic acid tert.-butyl ester

Product 1

HCID 185487134-(3-Imidazol-1-yl-phenyl)-8-pyrrol-1-yl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {2-[3-(3-imidazol-1-yl-phenyl)-3-oxo-propionylamino]-4-pyrrol-1-yl-phenyl}-carbamic acid tert.-butyl ester (Example M17) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (1.03 g).

Sources & evidence

ORD record
ord-ee45336a63964ed1bc70c8ef49871e76
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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