Trifluoroacetic acid → HCID 18548808, compound

HRID 1266842Notes

Reaction equation

HRID 1266842 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[C:11]([N:16]2[CH:20]=[CH:19][CH:18]=[CH:17]2)=[CH:10][C:9]=1[NH:21][C:22](=[O:34])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]#[N:33])[CH:27]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:15][O:14][C:12]1[C:11]([N:16]2[CH:20]=[CH:19][CH:18]=[CH:17]2)=[CH:10][C:9]2[NH:21][C:22](=[O:34])[CH2:23][C:24]([C:26]3[CH:27]=[C:28]([CH:29]=[CH:30][CH:31]=3)[C:32]#[N:33])=[N:7][C:8]=2[CH:13]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586972HCID 86586972, compound

Product 1

HCID 18548808HCID 18548808, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {2-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-5-methoxy-4-pyrrol-1-yl-phenyl}-carbamic acid tert.-butyl ester (Example M18) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (10 mg).

Sources & evidence

ORD record
ord-6e489d834290440b9fd215ecef12709e
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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