Trifluoroacetic acid → HCID 18548728, compound

HRID 1266845Notes

Reaction equation

HRID 1266845 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH:18]=[CH:17][CH:16]=[CH:15]2)=[CH:10][C:9]=1[NH:19][C:20](=[O:35])[CH2:21][C:22](=O)[C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([N:29]2[CH:33]=[CH:32][N:31]=[N:30]2)[CH:24]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:14]1([C:11]2[CH:12]=[CH:13][C:8]3[N:7]=[C:22]([C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([N:29]5[CH:33]=[CH:32][N:31]=[N:30]5)[CH:24]=4)[CH2:21][C:20](=[O:35])[NH:19][C:9]=3[CH:10]=2)[CH:18]=[CH:17][CH:16]=[CH:15]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586974HCID 86586974, compound

Product 1

HCID 18548728HCID 18548728, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {2-[3-oxo-3-(3-[1,2,3]triazol-1-yl-phenyl)-propionylamino]-4-pyrrol-1-yl-phenyl}-carbamic acid tert.-butyl ester (Example M20) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (36 mg).

Sources & evidence

ORD record
ord-adbc21c869f24820a2f18ed72558e113
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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