Ammonia → HCID 69780802, compound

HRID 1266853Notes

Reaction equation

C([O:3][C:4]([C:6]1[S:7][CH:8]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]3[CH2:18][C:19](=[O:33])[NH:20][C:21]4[CH:27]=[C:26]([N:28]5[CH:32]=[CH:31][CH:30]=[CH:29]5)[CH:25]=[CH:24][C:22]=4[N:23]=3)[CH:12]=2)[N:10]=1)=O)C.[NH3:34]>>[O:33]=[C:19]1[CH2:18][C:17]([C:13]2[CH:12]=[C:11]([C:9]3[N:10]=[C:6]([C:4]([NH2:34])=[O:3])[S:7][CH:8]=3)[CH:16]=[CH:15][CH:14]=2)=[N:23][C:22]2[CH:24]=[CH:25][C:26]([N:28]3[CH:32]=[CH:31][CH:30]=[CH:29]3)=[CH:27][C:21]=2[NH:20]1

Participants

Reactant 2

HCID 222Ammonia

HCID 697805714-[3-(4-oxo-7-pyrrol-1-yl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-phenyl]-thiazole-2-carboxylic acid ethyl ester

Product 1

HCID 69780802HCID 69780802, compound

Procedure

A sample of 4-[3-(4-oxo-7-pyrrol-1-yl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-phenyl]-thiazole-2-carboxylic acid ethyl ester (Example 28) (0.07 g) was reacted with ammonia in an analogous manner to the procedure described in Example 27 to give the title compound (0.05 g) as a light-yellow solid.

Sources & evidence

ORD record: ord-e1b6af9e3d074f8bbb1ddd2044c3b6f4
Source dataset: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06548495B2

Reaction notes

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