Diethanolamine → HCID 69779842, compound

HRID 1266854Notes

Reaction equation

HRID 1266854 reaction equation
CO[C:3]([C:5]1[N:6]=[C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]3[CH2:17][C:18](=[O:32])[NH:19][C:20]4[CH:26]=[C:25]([N:27]5[CH:31]=[CH:30][CH:29]=[CH:28]5)[CH:24]=[CH:23][C:21]=4[N:22]=3)[CH:11]=2)[O:8][CH:9]=1)=[O:4].[OH:33][CH2:34][CH2:35][NH:36][CH2:37][CH2:38][OH:39]>>[OH:33][CH2:34][CH2:35][N:36]([CH2:37][CH2:38][OH:39])[C:3]([C:5]1[N:6]=[C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]3[CH2:17][C:18](=[O:32])[NH:19][C:20]4[CH:26]=[C:25]([N:27]5[CH:28]=[CH:29][CH:30]=[CH:31]5)[CH:24]=[CH:23][C:21]=4[N:22]=3)[CH:11]=2)[O:8][CH:9]=1)=[O:4]

Participants

3

Reactant 2

HCID 8113DiethanolamineHCID 69779806HCID 69779806, compound

Product 1

HCID 69779842HCID 69779842, compound

Procedure

A solution of 2-[3-(4-oxo-7-pyrrol-1-yl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-phenyl]-oxazole-4-carboxylic acid methyl ester (Example 25)(88 mg) in 2-(2-hydroxy-ethylamino)-ethanol (2 mL) was stirred at 50° C. for 6 h. The mixture was partitioned between H2O and EtOAc. The organic layer was dried and evaporated in vacuum, and the residue was triturated with EtOAc to give the title compound (32 mg) as light-yellow solid.

Workup

  1. customThe mixture was partitioned between H2O and EtOAc
  2. customThe organic layer was dried
  3. customevaporated in vacuum
  4. customthe residue was triturated with EtOAc

Sources & evidence

ORD record
ord-314206fb984249868d7753525df40408
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

Loading…