Trifluoroacetic acid → HCID 18548928, compound

HRID 1266858Notes

Reaction equation

HRID 1266858 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([CH2:14][C:15]#[N:16])[C:11]([I:17])=[CH:10][C:9]=1[NH:18][C:19](=[O:34])[CH2:20][C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([N:29]2[CH:33]=[CH:32][N:31]=[CH:30]2)[CH:24]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:29]1([C:25]2[CH:24]=[C:23]([C:21]3[CH2:20][C:19](=[O:34])[NH:18][C:9]4[CH:10]=[C:11]([I:17])[C:12]([CH2:14][C:15]#[N:16])=[CH:13][C:8]=4[N:7]=3)[CH:28]=[CH:27][CH:26]=2)[CH:33]=[CH:32][N:31]=[CH:30]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586975HCID 86586975, compound

Product 1

HCID 18548928HCID 18548928, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {5-cyanomethyl-2-[3-(3-imidazol-1-yl-phenyl)-3-oxo-propionylamino]-4-iodo-phenyl}-carbamic acid tert.-butyl ester (Example M21) (520 mg, 0.89 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light pink solid (297 mg).

Sources & evidence

ORD record
ord-ce65b1857d1846889a2a08da1938bda8
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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