Trifluoroacetic acid → HCID 18548860, compound

HRID 1266860Notes

Reaction equation

HRID 1266860 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[C:11]([C:20]([F:23])([F:22])[F:21])=[CH:10][C:9]=1[NH:24][C:25](=[O:48])[CH2:26][C:27](=O)[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([C:34]2[O:38][N:37]=[C:36]([CH2:39][O:40]C3CCCCO3)[CH:35]=2)[CH:29]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[OH:40][CH2:39][C:36]1[CH:35]=[C:34]([C:30]2[CH:29]=[C:28]([C:27]3[CH2:26][C:25](=[O:48])[NH:24][C:9]4[CH:10]=[C:11]([C:20]([F:22])([F:21])[F:23])[C:12]([N:14]5[CH2:19][CH2:18][O:17][CH2:16][CH2:15]5)=[CH:13][C:8]=4[N:7]=3)[CH:33]=[CH:32][CH:31]=2)[O:38][N:37]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586977HCID 86586977, compound

Product 1

HCID 18548860HCID 18548860, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (RS)-[5-morpholin-4-yl-2-(3-oxo-3-{3-[3-(tetrahydro-pyran-2-yloxymethyl)-isoxazol-5-yl]-phenyl}-propionylamino)-4-trifluoromethyl-phenyl]-carbamic acid tert.-butyl ester (Example M23) (57 mg, 0.08 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (11 mg).

Sources & evidence

ORD record
ord-2824a923449e46a7a183ddd31bbfb2a9
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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