Trifluoroacetic acid → HCID 18548793, compound

HRID 1266876Notes

Reaction equation

HRID 1266876 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([C:15]([F:18])([F:17])[F:16])=[CH:10][C:9]=1[NH:19][C:20](=[O:32])[CH2:21][C:22]([C:24]1[CH:29]=[CH:28][N:27]=[C:26]([C:30]#[N:31])[CH:25]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:14][C:12]1[C:11]([C:15]([F:18])([F:17])[F:16])=[CH:10][C:9]2[NH:19][C:20](=[O:32])[CH2:21][C:22]([C:24]3[CH:29]=[CH:28][N:27]=[C:26]([C:30]#[N:31])[CH:25]=3)=[N:7][C:8]=2[CH:13]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586991HCID 86586991, compound

Product 1

HCID 18548793HCID 18548793, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {2-[3-(2-cyano-pyridin-4-yl)-3-oxo-propionylamino]-5-methyl-4-trifluoromethyl-phenyl}-carbamic acid tert.-butyl ester (Example M39) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (113 mg).

Sources & evidence

ORD record
ord-5a13c5bcb36946a5884f1ec4e2229c4a
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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